Leukocyte telomere length and physical ability among Danish Twins age 70+
نویسندگان
چکیده
منابع مشابه
Leukocyte telomere length, T cell composition and DNA methylation age
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age─ the extrinsic epigenetic age acceleration (EEAA)─ is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanM...
متن کاملChildhood Physical and Sexual Abuse History and Leukocyte Telomere Length among Women in Middle Adulthood
OBJECTIVE Abuse victimization in childhood is associated with a variety of age-related cardiometabolic diseases, but the mechanisms remain unknown. Telomeres, which form the protective caps at the ends of chromosomes, have been proposed as measures of biological age, and a growing body of research suggests that telomere attrition may help to explain relationships between stress and cardiometabo...
متن کاملLeukocyte telomere length and marital status among middle-aged adults.
BACKGROUND being unmarried is associated with worse health and increased mortality risk. Telomere length has emerged as a marker for biological ageing but it is unclear how telomere length relates to marital status. OBJECTIVE to examine the relationship between telomere length and marital status in a sample of middle-aged adults. DESIGN AND SUBJECTS cross-sectional analysis among 321 adults...
متن کاملLeukocyte telomere length: the telomere tale continues.
In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
متن کاملLeisure-time physical activity and leukocyte telomere length among older women.
BACKGROUND Shortened leukocyte telomere length (LTL), a purported marker of cellular aging, is associated with morbidity and mortality. However, the association of physical activity, a modifiable lifestyle behavior, with LTL has not been adequately studied among older adults. METHODS In this cross-sectional study, we examined associations of various intensity levels of leisure-time physical a...
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ژورنال
عنوان ژورنال: Mechanisms of Ageing and Development
سال: 2011
ISSN: 0047-6374
DOI: 10.1016/j.mad.2011.10.003